Perfil epidemiológico y hallazgos intraoperatorios de los Glioblastomas en el Servicio de Neurocirurgia del Hospital Santa Casa de Ribeirão Preto - SP - Brasil

Abstract

Introduction: Glioblastoma (GB) or Astrocytoma grade IV (WHO), represent 15-20% of CNS tumors and approximately 50% of gliomas in adults. Objective:Reveal the epidemiological profile of HSCMRP, correlate macroscopic and microscopic findings during surgery treated from January 2011 to November 2015. Method: Observational epimdeiological study, descriptive, retrospective, of medical records of 429 cases of intracranial tumors from data obtained from the files of the institution and pathological records of patients treated surgically. Results: Total tumors found 429 and 96 (22.37%) GB with a meanage of 59 years, predominant seventh decade of life 33%. A relationship between women and men was with little difference 1:1.12, respectively. The most common complaints were headache (58%), confusion (41%), hemiparesis 37%. Most prevalent comorbidities: hypertension (64%) and diabetes (22%) and smokers (24%). Most common opography were followed by left front lesions. The average time of onset of symptoms to surgery was 39 days. Complete resection in 76% of cases. The mean length of postoperative recurrence was 96 days, in 68% patients were noticed an exuberance of thrombosed vessels
during surgery. Pathological findings: necrosis 98%, atypical mitosis 96%, microvascular proliferation 73% and nuclear polymorphism
57%. Discussion: GB state of art. Conclusion: Our results are very slightly with the literature. The association of intraoperative observation thrombosed vessels, and tumor aggressiveness in patients with worse prognosis and shorter time to relapse, suggests that it is real, however, the small number of cases, needs further investigation, including other findings and immunohistochemical results.