Líquido cefalorraquideo y sistema glinfático, conceptos para no olvidar.

Abstract

The hydrodynamic theory of cerebrospinal fluid postulated (CSF) by Weed-Dandy-Cushing in the 20th century proposes the production, circulation and reabsorption of cerebrospinal fluid in a system called the third circulation that simulates the circulatory system. This theory is often insufficient to explain certain specific clinical problems such as the presence of agenesis of the aqueduct of Sylvius in the absence of hydrocephalus, the persistence of CSF after coagulation of the choroid plexus, etc. The new hypothesis proposed by Bulat Klarika Oreskovic is described, including more factors in hydrodynamics, understanding that this system does not escape from the biophysical laws that govern the rest of the human body, trying to explain from another point of view the same phenomena. Likewise, certain pathologies such as adult normal pressure hydrocephalus, idiopathic endocranial hypertension, among others, are better explained with this theory. The glymphatic system (GS) is described outside of these theories as a pathway through which the brain, through the perivascular space, can discard certain noxious substances that allow maintaining the normal physiology of the Central Nervous System. The present study attempts to explain in a simple way these theories and their relationship with the GS and some relevant pathologies.