Meningeomas Múltiples Intracraneales en ausencia de Neurofibromatosis. Reporte de caso y revisión de la literatura

Abstract

Multiple Meningiomas (MM) are defined as the appearance of at least two spatially separated meningiomas occurring at the same time, or more than two meningiomas that grow sequentially from two distinctly different regions, not necessarily from the same pathological subtype, without the presence of Neurofibromatosis. The MM were described for the first time in 1889; but they would be Cushing and Eisenhardt in 1938, the first to used the term Meningioma and define the meaning of Multiple Meningiomas or Meningiomatosis. This is a pathology with low incidence, generally with benign course and with a varied clinical presentation depending on the location of the meningioma. Currently, there is no clear pathophysiological description of the disease, however, celular alterations have been described, that promote a clonal dissemination in the meninges. Its approach must be carried out in a multidisciplinary manner, discarding mainly genetic disorders. Additionally, it is necessary to independently assess the patient’s clinical status and imaging findings to determine the need for surgical management. This is a case of a 48-year-old female patient attended at the Hospital Universitario Mayor, with a history of meningioma resection 10 years ago in pontocerebellar region and 2 years ago in frontal region, who is documented intracranial MM by magnetic resonance, with a negative study for neurofibromatosis.