Falla renal en el paciente con lesión medular aguda

Abstract

Spinal cord injuries constitute a catastrophic event related to significant physical disabilities and major socioeconomic implications. Among its complications, renal failure is related to increased morbidity and mortality. Amidst all the proposed pathophysiological mechanisms of the disease, the ones that stand out are the imbalance in the regulatory functions of the autonomic nervous system, the systemic inflammatory state resulting from the exponential activation of circulating inflammatory cells, and the rhabdomyolysis resulting from trauma. These physiological changes that lead to kidney failure affect the metabolism of different drugs, particularly those with renal elimination. The intracellular components of the inflammatory machinery, including enzymes and transcription factors, can also serve as therapeutic targets to resolve inflammation in multiple organs following a spinal cord injury.